NAD+ science & education

NAD Educational Videos

Everything you need to know about NAD IV. Dr. Payam Hakimi explains the many benefits and mechanisms of NAD and talks about what it feels like to receive an infusion in this 15-minute video.

Dr. Ken Star talks about the importance of using NAD to treat substance withdrawal abuse by qualified professionals. NAD works best to ameliorate the effects of alcohol and/or opiate withdrawal. 

Patient Experience: Paul talks about his experience with IV NAD and it helped his chronic fatigue as well as his mood. 

Dr. Mike explains the biochemistry of NAD+ and its role in ATP (energy) generation.  

NAD- Scientific Studies

The significance of NAD+ in addictive disorders stems from the work of Dr. Paul O’ Hollaren (1961) who claimed to have successfully utilised IV NAD+ for the prevention and treatment of over 104 cases of addiction to alcohol and other drugs of abuse, including heroin, opium extract, morphine, dihydromorphine, meperidine, codeine, cocaine, amphetamines, barbiturates and tranquilisers. NAD+ is likely to represent a cheap and useful holistic approach for the estimated millions of addicts worldwide, and may be an effective adjunct to psychotherapy, by ameliorating symptoms of physical addiction through a variety of mechanisms. IV NAD+ remains the most direct method of raising NAD+ levels, although it is yet to gain U.S. Food and Drug Administration (FDA) approval. While data from experimental studies are limited, significant clinical benefit of IV NAD+ infusion in alcohol and opioid withdrawal has been previously reported. These authors found significant improvements in the removal of cravings and withdrawal symptoms. The benefits of NAD+ are likely to be extended to improving emotional disorders in patients with psychological disorders. Whilst there has been growing enthusiasm for the benefits of IV NAD+ therapy, the pharmacokinetics and pharmacodynamics of IV NAD+ remain nascent in the current literature.

Diphosphopyridine nucleotide in prevention, diagnosis and treatment of drug addciton. A preliminary report. West J. Surg Obstet Gynecol. 1961 May-Jun: 69:213-5

Intravenous Administration of Nicotinamide Adenine Dinucleotide Significantly Reduces Self Report Craving Ratings Associated with Opiate and Alcohol Withdrawal*- March 2020

Sobriety and Satiety: Is NAD+ the Answer? – Antioxidants (Basel). 2020 May 14;9(5):425. doi: 10.3390/antiox9050425.

Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases – July 2022

Basic science research has demonstrated that NAD+ plays a critical role in many brain processes including tissue repair, decreasing neuroinflammation, adequate learning, and memory formation. NAD+ is a key signaling molecule that controls cell function and regulates major biological processes including calcium homeostasis, energy metabolism, mitochondrial functions, cell death, and aging. Levels are known to decline with age and are believed to be one of the contributors to the many disorders of aging. Further studies on the use IV NAD+ in humans are still underway. 

NAD+ and NADH in brain functions, brain diseases and brain aging- Front Biosci – 2007 Jan 1;12:1863-88. doi: 10.2741/2194

NAD+ in Brain Aging and Neurodegenerative Disorders – Cell Metab 2019 Oct 1; 30(4): 630-655. doi: 10.1016/j.cmet.2019.09.001

Kynurenine Pathway Pathologies: do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) – Int J Tryptophan Res. 2013 Jul 21;6(Suppl 1):39-45. doi: 10.4137/IJTR.S11193. 

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence – Cell Metab. 2018 Mar 6; 27(3): 529-547. doi: 10.1016/j.cmet.2018.02.011

Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals (Basel). 2020 Sep; 13(9): 247 doi: 10.3390/ph13090247