Ketamine Treatment


What is IV Ketamine?

Ketamine is an FDA-approved anesthetic agent that is used off-label (much like 45% of psychiatric medications are used off-label) for the treatment of specific mental health and chronic pain conditions. It has a remarkable safety track record, is on the World Health Organization (WHO) list of essential medications, and has a unique mechanism unlike any other drug used. Scientific studies show ketamine can add new nerve cells (neurogenesis) and connections between nerve cells (synaptogenesis) within hours of treatment. This is why the effect tends to occur so quickly and has been shown to be effective in over 70% of depressed patients. 

Ketamine can be administered by different routes including IV (intravenous), IM (intramuscular), SQ (Subcutaneous), and/or Oral/Sublingual. The IV route is considered the gold standard, with the highest safety profile, and the only route that offers 100% bioavailability. At Relevare we follow the latest scientific data for treatment implementation alongside integration services to maximize the benefits from treatment. 

Ketamine lies in the frontier of mental health treatments and has been endorsed by both the NIMH (National Institute of Mental Health) and APA (American Psychiatric Association) as a safe and effective treatment for depression. It has been discovered to be highly effective in treating other conditions such as anxiety, PTSD, migraines, OCD, and more. 

The RDS foundation recommends ketamine infusions for the treatment of CRPS as well as other neuropathic pain disorders. Chronic pain conditions such as phantom limb pain (PLP) and chronic migraines have also shown benefits. 

Feel free to visit our Ketamine FAQ page for answers to frequent questions and contact us to schedule your free 15-minute phone consult with Dr. Mallek today. Your contact information will always be kept private and will never be sold to third-party vendors.

What is included with Ketamine
treatments at Relevare?

Ketamine is an extremely powerful tool that can quickly and effectively boost mood and motivation and should be used wisely. The IV treatment lasts only 40 minutes. Any adjuvant medication needed to treat nausea, anxiety, headache, blood pressure, etc is included in the price. You will have a private room and one-on-one care. The effects of the ketamine subside 15-45 minutes after the infusion ends however, the beneficial brain changes continue for days following treatment. This is where integrating the right behaviors and thought patterns becomes key to increasing the probability results will be long-lasting. We will help guide you in preparation for your ketamine journey as well as post-treatment life integration. 

Ketamine is NOT a miracle or panacea. In life, there will always be sadness, anxiety, pain, and other subjective negative emotions. With the rapid boost in mood and the unique change in outlook ketamine provides it becomes significantly easier to integrate needed changes in our lives. If one simply has the IV treatments and returns to the same old behaviors and thought patterns there is an increased chance you will slide back into the same old moods. 

“We suffer more often in imagination than in reality”
                                                                      – Seneca

Dr. Mallek is an MD, board-certified anesthesiologist who has completed training on the Fundamentals of Ketamine Assisted Psychotherapy and is passionate about addressing root causes and relieving suffering. A thorough 1-1.5 hour intake evaluation is performed before your treatment series starts. During this time your medical & psychiatric history is reviewed alongside a full biopsychosocial assessment. This is where we really get to know who you are as a person and what a life worth living means to you. This way we can individualize your treatment plan to suit your specific goals.

Conditions We Treat

Evidence-based holistic treatments to help you live your best life.

How Does Ketamine work?
Chemically speaking...

Ketamine has a unique mechanism of action. It doesn’t simply increase the amount of serotonin or dopamine. It activates downstream pathways in the brain that result in the growth of new neurons and connections between neurons within hours of an infusion. This is why the effects are so fast and the applications rather broad. 

Ketamine is known to act on the NMDA receptor as an antagonist, meaning it blocks the action of that receptor. In addition, ketamine also acts on the AMPA receptor (an action of R-ketamine that is missing from the nasal spray Esketamine). The downstream effect of the action on both these receptors results in modulating signals and decreasing the amount of glutamate, a major neurotransmitter inside the brain.

Glutamate is actually involved in more than 90% of all excitatory functions in the human brain. This is why it is so useful for so many disorders including anxiety. With the inhibition of glutamate, you get an increase in brain-derived neurotrophic factor (BDNF). This is where the formation of new neurons (neurogenesis) and new pathways (synaptogenesis) happens. Ketamine works, unlike no other medication.

In addition to its action on NMDA and AMPA as stated above (which is thought to be the primary mechanism), it is also effective on aminergic, opioid, and cholinergic systems. This could also contribute to behavioral and neural network changes, which is exactly what we want. There are multiple studies showing how ketamine can help those with various mental health and chronic pain conditions. Please visit our Science & Education link to watch entertaining educational videos and read through some of the more pertinent scientific studies. 

Ketamine starts working within hours. The effects of ketamine are fast following an infusion however there is data to show that these effects typically last only a week if a single infusion is done. A full treatment series has more long-lasting results which is why a treatment series of 6 is recommended. We want to make sure that these new brain cells are making the right connections therefore we use integration sessions with your treatments to help you with the right thought patterns and behaviors so that these effects can last as long as possible.

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